Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Obama enters his second four-year term faced with a difficult task of tackling $1 trillion annual deficits, reducing a $16 trillion national debt, overhauling expensive social programs and dealing with a gridlocked U.S. Congress that looked likely to maintain the same partisan makeup。
“The consumer will take a little more time to come back which is why we’re focusing on a game plan we know that works, focusing on affordability and premium [drinks] in metro areas,” he said, adding that he is confident that the company can continue to gain share in the country and is set up for when consumer spending picks up again.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
But what will politicians actually do While President Trump is focused on bringing back traditional manufacturing jobs to America, different US states are experimenting with other policies to help low-paid precarious workers. These range from sharply higher minimum wages to new rules to stop employers changing staff schedules at the last minute.
The fruit is placed into the mold when it's young and undeveloped.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Civil War takes place after the events of Avengers: Age of Ultron, when the government decides that the Avengers should work under them and not on their own. Steve Rogers, aka Captain America, is against this idea whereas Tony Stark, aka Iron Man, is with the government. This leads to a conflict between Captain America and Iron Man.
尽管在2008 年9 月被任命为美国时代华纳集团旗下《型时代》杂志总编辑的阿里尔·福克斯曼是榜单新人，很少参加电视节目，但他的时尚总监哈尔·鲁本斯坦现在是美国“一生” 女性频道《幻彩魔刷：寻找下一个化妆大师》节目的评委。福克斯曼的刊物在广告页数上领先，据称在2009 年上半年总计超过1000 页。
Trends and targets in antiviral phototherapy
Homing in on a brand that excels at making the kind of vehicle you’re looking for is an efficient way to focus your shopping and find the best car for you. The 2016 U.S. News Best Vehicle Brand awards recognize the best brands in four categories: Cars, SUVs, Trucks and Luxury.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Those quickly sold out, locking out the vast majority of fans in soccer-mad Brazil.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
We will boost the development of modern agriculture.
ACE2 as a potential therapeutic target for pandemic COVID-19
Promote steady development of agriculture and continued increases in rural incomes
自2005年以来，年度最佳商业图书奖的评奖标准一直是“对现代商业问题提供了最令人叹服且最有趣味的深刻见解”。2014年的获奖者是托马斯皮凯蒂(Thomas Piketty)的《21世纪的资本》(Capital in the Twenty-First Century)。
Diagnostic technologies for COVID-19: a review
Emerging market exports have been declining in dollar terms since October 2014, a far longer, if less extreme, losing streak than during the 2008-09 global financial crisis, as the first chart shows.
New Year's greetings and best wishes!
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
To make sure the plan goes through, the central government must reinforce the plan to co-ordinate basic pension, enhance enterprise annuity and manage personal accounts properly, Yang said.
The 5.5-percent increase this year is reasonable given a less anticipated consumer price index (CPI) as well as slower salary and GDP growth, said Jin Weigang, head of the social security research institute under the MOHRSS.
贝恩公司(Bain & Company)也正处于变革之中，去年11月该公司宣布曼尼马塞达(Manny Maceda)将于2018年3月成为其全球领导人，从鲍勃博切克(Bob Bechek)手中接管这家总部位于波士顿的咨询机构；马塞达将是该公司首位亚洲血统的掌门人。专家们表示，马塞达可能推动该公司开拓新的专长领域，并摆脱业务多而不精的名声。
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The pace of Japanese production rose at a brisk clip during the month of October, giving policymakers hope - if not more mixed messages - about the strength of the Japanese economy.
JUSTIFIED (FX, Jan. 20) The series-long love-hate relationship between Deputy Marshal Raylan Givens (Timothy Olyphant) and his friend and nemesis Boyd Crowder (Walton Goggins) will be resolved, one way or another, in the show’s sixth and final season.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
Volatility in currency markets is also likely to be a factor for agricultural commodity prices in the next 12 months, with the euro likely to depreciate as a result of French, Dutch and German elections, Rabobank reckons.
"How to tie a tie" was the No. 1 question in 2010, followed by "how to lose weight", "how to kiss" and "how to write a resume."
Influenza neuraminidase: A druggable target for natural products
When many millennials struggle to find jobs or make do in low-skilled positions, these masters programmes achieve strong employment rates thanks to their links with corporate partners and alumni networks.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
But the economic base for these capabilities is steadily declining.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The director Bennett Miller saw Mr. Carell as a good choice to play du Pont but didn’t want him to be too recognizable. He charged the makeup designer Bill Corso with the task of altering Mr. Carell’s look.
1.《刺客聂隐娘》(The Assassin)与《疯狂的麦克斯4：狂暴之路》(Mad Max: Fury Road)，并列。侯孝贤和乔治·米勒(George Miller)导演了今年最好的两部商业片，二者都应该到你能找到的最大的屏幕上去看。
At school, even in kindergarten, you teach us to behave in the world. You teach us: not to fight with others, to respect others, to clean up our mess, not to hurt other creatures, to share - not be greedy. 在学校，甚至在幼稚园，你们大人教我们如何处世，你们告诉我们不要打架，要尊重对方。找出答案，解决矛盾。去分享，而不是贪婪。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
This year they looked at the use of negative strategies such as anger or stonewalling responses to conflict, and found that these predicted health-related changes over time in specific ways.
Inhibition of SARS coronavirus helicase by bismuth complexes
Why the difference? It wasn’t because of a difference in the available information. As Koudijs and Voth point out, everybody in Dutch financial circles knew and understood the magnitude of what had happened. Nor was it because the Seppenwolde lenders had to rebuild their own finances. Within weeks of the default, the lenders knew they hadn’t lost any money.
TextPride was a fine business, but a tiny one. Meanwhile, the market for messaging apps was exploding. Facebook FB 0.61% bought WhatsApp for $19 billion; that service now has 700 million monthly active users. Tango, an app with 250 million registered users, is worth $1.5 billion. Kik has 200 million registered users. Snapchat, worth $10 billion, has 100 million users. A new study, commissioned by Kik, shows that U.S. users now spend more time on average in messaging apps than they do on social networking apps. The only problem? These messaging apps need ways to make money, and there’s no reasonable way for advertisers to wedge themselves into conversations between friends.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
James Bond Themes 4. "Thunderball" by Tom Jones
4. Adidas. Brand love: 35% / Rank 25
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Local farmers must love this wireless company as much as its employees do. Once a week, San Diego-based Qualcomm hosts a farmers market at two of its locations. Items sold range from traditional produce to jams and jellies. Employees with CSA veggie box subscriptions can pick up their produce packages at one of the HQ's cafés.
May the beauty and joy of New Year remain with you throughout the new year!
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The developer behind Kinect Disneyland Adventures and Elite: Dangerous is taking the theme park business to the extreme in ScreamRide. The game lets players build outrageous roller coasters, thrill rides and attractions from the ground up and then take them for a test run. The game offers three ways to play: Engineers can construct elaborate rides that test the boundaries of physics and g-forces; Scream Riders get on these rides and experience the thrills and spills first-hand – sometimes resulting in untimely deaths; and Demolition Experts can use any means necessary to tear down an entire amusement park. With classic PC games like Roller Coaster Tycoon now playable on smartphones, this next generation of thrill-ride creator is a welcome interactive experience. It’s always fun to build, ride and destroy roller coasters – and ScreamRide offers plenty of ways to share the thrills with your friends.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Yes — by an eyelash. Democrats will need to win an additional 24 seats, meaning they will have to hold on to all 12 Democratic districts that Mr Trump won last year and pick up the 23 Republican districts that voted for Hillary Clinton, plus one or two more for good measure. The math is not on the Democrats’ side, but history is. The president’s party almost always loses some House seats in the midterms, and sometimes loses big, especially when the president has an approval rating below 50 per cent. See Barack Obama in 2010.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
"Investing in improving innovation quality is essential for closing the innovation divide," said Soumitra Dutta, dean of Cornell College of Business and co-editor of the report.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The movies were selected from more than 2,000 titles from 100 countries and will be screened in 30 cinemas and colleges around Beijing from April 8 to April 23, Zhang Xiaoguang, deputy head of China Film Archive, said last Thursday.
May the coming New Year bring you joy, love and peace.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
I will be yours forever!我永远属于你！
I am here to speak for the countless animals dying across this planet because they have nowhere left to go. We cannot afford to be not heard. 我为这个行星上无数正在垂死的动物而演讲，因为它们几乎已经无处容身了。
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Just because the job market is tough doesn't mean it's impossible. "You have to work harder at the job search," Challenger said.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
It has to take over most of every waking minute. It's all you want to talk about. Prepare to watch people's eyes glaze over.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Yes, some molds cause allergic reactions and respiratory problems. And a few molds, in the right conditions, produce "mycotoxins," poisonous substances that can make you sick.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
'The pizza is extremely rich - if you're in the mood for a lavish meal, this is the pizza for you,' he said.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Pan Jiancheng, deputy head of the bureau's China Economic Monitoring and Analysis Center, said the increasing proportion of research and development expenditure to GDP indicates that the driving force of economic growth is transforming to innovation-focus from the traditional factors - exports and investment.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
The slower acceleration also tracks with trends in real estate investment, which felt a (slight) bite from property purchasing curbs in top-tier cities last month as nation-wide sales also decelerated in both volume and value terms.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
City on the Silk Road
China will "fasten the seat belt" and prevent any "acute outburst" of financial risks on the track for maintaining medium-high growth speed.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
7.You Haven't Gotten a Raise in the Last Two Years
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Hurricane Irma topped the search charts in both the U.S. and globally with Matt Lauer being the most searched for person in the U.S. and the world. Here’s the rundown of the top 10’s in the U.S. and globally:
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
For: It picked up the audience award at the Toronto International Film Festival, often a key awards indicator.
The U.S. $10 bill will feature the portrait of a notable U.S. woman by 2020.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Mary J. Blige, Miguel, Gael García Bernal, Andra Day, Natalia LaFourcade, Keala Settle, Sufjan Stevens and Common will perform their original songs at the Dolby Theatre in Hollywood on March 4, when the motion picture academy kicks of its 90th Oscars ceremony.
By more than one measure, 2014 is a year the Honda Motor Co. would prefer to forget or to obscure, reflected in a roundabout way by its grand slogan for 2015, “The Year of Honda.”
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A strong performance in all four rankings for LBS includes first place for its full-time MBA programme and third for both its joint Executive MBA programme (taught with Columbia Business School in the US) and customised executive education.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The EU filed just 12 anti-dumping cases in 2015, two less than the year before.
这封情书是寄给一个叫做Clark C Moore，但是现在已经改名为Muhammad Siddeeq先生的，由于这次改名，让这封信找到真正的收件人变得尤为困难。
6. 米兰达·兰伯特(Miranda Lambert)，《白金》(Platinum)，RCA Nashville。兰伯特很快从坚强的新贵蜕变为光芒四射的乡村乐贵族，这张《白金》是她最好的专辑，她带着轻松的权威之感逾越了界限。专辑中伤感与世俗的情绪交替出现，修饰和粗粝的比例恰到好处，这张专辑让人们明白她有着强大的力量，向任何低估她实力的人发出挑战。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Piano and ballet performance “On My Fingertips And Toes” (Lang Lang and Hou Honglan)
Murietta belonged to a gang known as the Five Joaquins, who were notorious bandits during the height of the California Gold Rush. While Murietta's criminal activity likely did not have any political undertones, he nonetheless became a symbol of Mexican resistance as American settlers ventured to California. Unfortunately for him, this pushed the government to put a bounty on his head, leading to his murder and beheading. Luckily, Banderas's character didn't fall to the same fate.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
TV soaps regularly top the TV ratings but the highest trending show of 2012 was the BBC kids' show 'Mike The Knight' that beat US terror drama 'Homeland' and 'Towie.'
"Hiring a veteran can be one of the best decisions any of us can make, and Wal-Mart is proud that we have hired more than 26,000 since we announced our Welcome Home Commitment on Memorial Day," Simon told Fortune. "Veterans have a strong record of performance under pressure and passion for service, which makes our pledge to hire, learn from, and support them easy."
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Honda has recalled more than 10 million vehicles in the U.S. to fix a potentially fatal defect in air bags made by Japanese supplier, Takata. The air bag inflators can rupture after a crash and injure occupants with shards of metal. Honda has confirmed three deaths and 48 injuries in connection with such incidents.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
4. Am I eating healthy? The types of foods we eat can greatly affect how we feel both physically and emotionally. Eating too much junk food can lead to crankiness and a relatively low energy level, whereas eating healthy foods can lead to better moods and a more positive energy level.
Length-scale dependence of protein hydration-shell density
Wuxi, in coastal Jiangsu province, retained the top spot for a second month with growth of 4.9 per cent,
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
这个领域的创新速度非常快。自从Fitbit于2008年成立以来，各家公司已经发布了五到六个完全不同的产品。三星（Samsung）则在九个月内发布了可穿戴设备Galaxy Gear的三到四个衍生产品。索尼（Sony）、Pebble、谷歌和Facebook的头戴式虚拟现实设备Oculus Rift也紧随其后。
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
9.The Company Isn't Doing Well
About this collection
No.3: Diamond Is So Obsolete